Saints fall to 0-2 in a home loss to San Francisco, with Alvin Kamara-volume fueling the offense and Carl Granderson anchoring a sharper Saints rush defense. San Francisco used a depleted roster effectively, leaning on a run-first approach and a steadier game plan with Mac Jones stepping in. Spencer Rattler showed signs of competence but remains winless as a starter, while New Orleans must fix the pass defense and capitalize on Kamara’s workload to stay afloat in fantasy leagues.

Chargers vs. Raiders in Las Vegas sets the stage for a high-stakes AFC West clash, pairing a momentum-rich Los Angeles squad with a Vegas defense that stifled New England. The pageantry includes a storied Harbaugh-Carroll rivalry that colors coaching chess on the sidelines. Vegas leans on a dynamic aerial attack led by Geno Smith in his Raiders debut, while the Chargers rely on Justin Herbert and a capable receiving corps to expose the Raiders’ defense. Injuries shape the lineups, adding urgency to a game that could tilt the division race.